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Updated: Jul 11, 2025

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

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通过CD86通过B细胞介导的CD4T细胞共刺激会在自身免疫性肠炎期间加剧促炎性细胞因子的产生

Iana Gadjalova1, Julia M Heinze1, Marie C Goess1

  • 1Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine, Munich, Germany; TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany.

Mucosal immunology
|November 2, 2023
PubMed
概括

激活的B细胞,特别是CD86表达,通过增加T细胞细胞因子的产生,使炎症性肠病 (IBD) 恶化. 针对B细胞或CD86信号的疗法在IBD模型中减少了肠道炎症.

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