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了解和利用O-GlcNAc在神经退行性疾病中的作用

Matthew R Pratt1, David J Vocadlo2

  • 1Department of Chemistry and Department of Biological Sciences, University of Southern California, Los Angeles, California, USA.

The Journal of biological chemistry
|November 2, 2023
PubMed
概括

在神经退行性疾病中,O-GlcNAc的修饰及其通过O-GlcNAcase (OGA) 的去除至关重要. OGA 抑制剂在治疗阿尔茨海默氏症和帕金森症方面表现有前途,临床试验正在推进.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.这就是O-GLcNAcc.临床发展 临床发展酶抑制剂是一种酶抑制剂.神经退行症的神经退行症蛋白质合成 蛋白质合成一个同核蛋白.知道的 知道的 知道的

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