瘤微环境调节CaCO3 -基于体体微反应器通常可以加强癌症免疫疗法
Ziliang Dong1,2, Yan Liu3, Chunjie Wang1
1Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu, 215123, P. R. China.
Advanced materials (Deerfield Beach, Fla.)
|November 2, 2023
概括
这项研究开发了一种新的微反应器,以中和瘤酸度和缺氧,提高癌症免疫治疗的有效性. 这种方法可以提高免疫检查点阻断和CAR-T细胞治疗对固体瘤的疗效.
科学领域:
- 生物医学工程 生物医学工程
- 癌症免疫疗法癌症免疫疗法
- 纳米技术纳米技术
背景情况:
- 瘤缺氧和酸性阻碍癌症免疫疗法通过损害免疫细胞.
- 固体瘤通常表现出这些免疫抑制的微环境.
- 需要新的策略来克服癌症治疗中的这些挑战.
研究的目的:
- 开发一种用于调节瘤微环境的多功能微反应器.
- 研究微反应器与现有免疫疗法的联合治疗效果.
- 为了提高免疫检查点封锁和CAR-T细胞疗法的疗效.
主要方法:
- 在碳酸纳米颗粒组装的化体 (CCaP CSs) 中使用双乳液方法封装化物.
- 内注射CCaP CSs以中和酸性和缺氧.
- 在小鼠瘤模型中评估CCaP CSs与抗PD-1抗体和EGFR-CAR-T细胞的结合.
主要成果:
- CCaP CSs有效地清理了质子,分解过氧化,并抑制了乳酸盐的产生.
- 用CCaP CSs治疗激活了抗瘤免疫力,并在CT26和4T1异体移植中增强了抗PD-1抗体的有效性.
- 在三阴性乳腺癌异种移植模型中,CCaP CSs显著改善了EGFR-CAR-T细胞透和细胞因子分泌.
结论:
- 化学调节瘤酸度和缺氧可以逆转免疫抑制.
- CCaP CSs代表了一种有前途的策略,可以加强免疫检查点阻塞和CAR-T细胞免疫疗法.
- 这种方法为改善固体瘤治疗结果提供了一条新的途径.
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