怀孕期间的COVID-19 - 胎盘的组织病理性病变
Julia Kummer1, Giada Ameli1, Anja Jebens1
1Department of Gynecology and Obstetrics, Vivantes Klinikum im Friedrichshain, Berlin, Germany.
Zeitschrift fur Geburtshilfe und Neonatologie
|November 2, 2023
概括
孕妇的COVID-19感染显著增加了胎盘病变,影响了母亲和胎儿的健康. 组织病理学分析显示,SARS-CoV-2会引起血管病变和炎症,影响胎盘状功能并增加风险.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- 在COVID-19大流行期间,孕妇及其后代是脆弱人群.
- SARS-CoV-2 感染可以通过胎盘病变间接影响胎儿健康,从而损害小功能.
- 与健康对照对象相比,对感染SARS-CoV-2的母亲的胎盘进行了组织病理学分析.
研究的目的:
- 为了调查与SARS-CoV-2感染分娩的胎盘的组织病理变化.
- 确定SARS-CoV-2感染和胎盘异常之间的关联.
- 评估胎盘病变对围产期结局的影响.
主要方法:
- 在2022年2月至2022年7月期间,进行了前性病例控制研究.
- 分析了36名SARS-CoV-2-阳性分娩者和35名健康对照者的胎盘样本.
- 记录和统计分析了患者病史,COVID-19症状和产科结果.
主要成果:
- 感染SARS-CoV-2显著增加了胎盘病变的风险 (OR 3.000,p=0.0001).
- 组织病理学异常,包括血管和炎症变化,急性缺血性心脏病发作和下血栓,在66.7%的感染母亲的胎盘中观察到.
- 胎盘病变没有显著影响围产期酸性病变或剖腹产次数.
结论:
- 在分娩和分娩期间感染SARS-CoV-2与不良结果的风险增加有关.
- 组织病理学发现证实,胎盘受到SARS-CoV-2的影响,导致全身血管病变和炎症.
- 胎盘是受到SARS-CoV-2感染影响的关键母胎界面.
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