衰老指标与慢性阻塞性肺病之间的关系,肺功能:NHANES的横截面研究,2007-2010年
Zhishen Ruan1, Dan Li1, Di Huang1
1Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
BMJ open
|November 2, 2023
概括
通过表型年龄加速 (PhenoAgeAccel) 测量加速的生物衰老与发展慢性阻塞性肺病 (COPD) 和肺功能减弱有关. 这突显了抗衰老疗法对COPD患者的潜在益处.
科学领域:
- 老年学和呼吸系统医学
- 衰老的生物标志物
- 肺部疾病研究研究
背景情况:
- 慢性阻塞性肺病 (COPD) 与衰老有很强的关联,但时间学年龄是对生物衰老的不足衡量标准.
- 现型年龄加速 (PhenoAgeAccel),即生物年龄和时间年龄之间的差异,为评估衰老提供了一个新的指标.
- 了解PhenoAgeAccel和COPD之间的联系对于开发有针对性的干预措施至关重要.
研究的目的:
- 为了调查PhenoAgeAccel和COPD的流行率之间的联系.
- 检查PhenoAgeAccel与肺功能客观测量的关系.
- 探索吸烟和呼吸道症状等因素如何与COPD的背景下与PhenoAgeAccel相关.
主要方法:
- 一项采用2007-2010年国家健康和营养检查调查 (NHANES) 数据的横截面研究.
- 40岁以上的参与者被归类为COPD,如果经过支气管扩张的FEV1/FVC<0.70.
- 线性和逻辑回归分析,包括子组分析和多种模型,用于评估PhenoAgeAccel对COPD和肺功能的影响.
主要成果:
- 更高的PhenoAgeAccel显着与COPD的可能性增加有关 (OR为Q4与Q1 = 1.52) 和肺功能降低.
- 升高的PhenoAgeAccel在COPD患者,老年人和白人参与者中对肺功能产生了更明显的影响.
- 呼吸系统症状和高吸烟指数与更高的PhenoAgeAccel相关,表明加快衰老.
结论:
- 根据PhenoAgeAccel的指标,加速的生物衰老是COPD发展和肺功能下降的重要因素.
- 这些发现表明,戒烟和抗衰老疗法可能具有治疗COPD的治疗潜力.
- PhenoAgeAccel 作为一个有价值的生物标志物,用于评估呼吸系统健康中与衰老相关的风险.
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