在癌症进展中的HMGB1信号介导瘤免疫
1Beijing Institute of Dental Research, Beijing Stomatological Hospital & School of Stomatology, Capital Medical University, 100050 Beijing, China.
Frontiers in bioscience (Landmark edition)
|November 2, 2023
概括
高流动性组盒1 (HMGB1) 在瘤免疫力中具有双重作用,既起到免疫抑制作用,又起到抗瘤反应的增强作用. 了解HMGB1的理解
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 瘤免疫包括从抗原释放到瘤细胞破坏的循环.
- 高流动性组盒1 (HMGB1) 是细胞释放的核蛋白,起到促炎媒介的作用.
- HMGB1的功能是由其环境,受体,氧化还原状态和翻译后修饰 (PTM) 调节的.
研究的目的:
- 审查高流动性组框1 (HMGB1) 在瘤免疫中的双重作用.
- 详细介绍HMGB1对调节性T细胞 (Tregs),骨髓原抑制细胞 (MDSCs) 和瘤相关巨细胞 (TAMs) 的免疫抑制作用.
- 探索HMGB1的抗瘤免疫增强效应,包括免疫细胞死亡 (ICD).
主要方法:
- 关于HMGB1在瘤免疫中的当前研究的文献综述.
- 对HMGB1参与免疫抑制细胞群 (Tregs,MDSCs,TAMs) 的分析.
- 检查HMGB1在促进抗瘤免疫反应中的作用,如ICD.
主要成果:
- HMGB1在瘤免疫中表现出复杂的双重作用.
- HMGB1可以通过促进Tregs,MDSCs和TAMs来抑制抗瘤免疫力.
- HMGB1还可以增强抗瘤免疫力,特别是通过免疫细胞死亡 (ICD).
结论:
- HMGB1的多方面的功能为癌症免疫治疗带来了挑战和机遇.
- 进一步研究HMGB1的机制对于开发有效的抗瘤策略至关重要.
- 准HMGB1可能是新型癌症免疫疗法的一个有希望的途径.
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