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Updated: Jul 11, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
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Published on: December 27, 2016

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马普酶ERK5调节癌细胞对死亡受体激活剂诱导的外部亡的敏感性

Sergio Espinosa-Gil1,2, Saska Ivanova3,4, Elisenda Alari-Pahissa5

  • 1Departament de Bioquímica i Biologia Molecular and Institut de Neurociències. Facultat de Medicina, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

Cell death & disease
|November 3, 2023
PubMed
概括

通过降解TP53INP2.2,MEK5-ERK5通路促进了癌细胞对TRAIL治疗的抵抗力. 抑制ERK5稳定TP53INP2,使癌细胞对TRAIL诱导的亡敏感,并提高治疗疗效.

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