在基于利法素的结核预防疗法之前,期间和两个月后,肠道微生物群的组成和多样性
Marie Nancy Séraphin1,2, Julia Bellot3,4, Emily Klann4,5
1Department of Medicine, Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL, USA. nseraphin@ufl.edu.
Scientific reports
|November 3, 2023
概括
使用利法素的较短结核病预防治疗 (TPT) 方案改变了肠道细菌,减少了有益的微生物,增加了潜在的有害微生物. 治疗后两个月,肠道微生物群的恢复不完全.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 结核病 (TB) 预防疗法 (TPT) 对于在低发病率地区消除结核病至关重要.
- 较短的TPT疗程与利法素旨在改善患者的坚持.
- 基于里法米辛的TPT可能会影响肠道微生物群.
研究的目的:
- 为了研究基于利法素的TPT对肠道微生物群组成的直接影响.
- 评估TPT完成后两个月内肠道微生物群的恢复情况.
主要方法:
- 使用16S rRNA amplicon测序 (V1-V2区域) 来分析肠道微生物群.
- 该研究包括6名患有潜在结核病感染 (LTBI) 的TPT患者和6名健康对照.
- 在TPT前,期间和两个月后分析了微生物群组成.
主要成果:
- TPT解释了肠道微生物社区不相似性的17%的差异.
- 基于利法胺素的TPT诱导了失生症,其特点是酸盐生产者的耗尽 (例如,Clostridium-XIVa,Roseburia).
- 在Firmicutes和Proteobacteria族群中观察到潜在的致病性类型的扩张,TPT后的恢复不完全.
结论:
- 基于利法胺素的TPT显著改变了肠道微生物群的组成,诱导了失生症.
- 在完成TPT后的两个月内,肠道微生物的恢复不完全.
- 需要进一步的临床研究来了解和减轻TPT诱导的肠道失调的潜在长期影响.
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