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Updated: Jul 11, 2025

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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对体突变的多实例学习用于瘤类型的分类和微卫星状态的预测

Jordan Anaya1, John-William Sidhom2,3,4, Faisal Mahmood5,6,7,8,9

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Nature biomedical engineering
|November 3, 2023
PubMed
概括

这项研究引入了一种新的深度学习模型,用于分析基因组数据,改进瘤类型分类和微观卫星状态预测. 该模型通过识别样本级分析的重要基因组特征来增强可解释性.

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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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