通过在工作记忆训练期间进行多次跨头直流刺激,持续提高神经效率
Yufeng Ke1,2, Shuang Liu3,4, Long Chen5,6
1Academy of Medical Engineering and Translational Medicine, Tianjin International Joint Research Centre for Neural Engineering, and Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, Tianjin, PR China. clarenceke@tju.edu.cn.
NPJ science of learning
|November 3, 2023
概括
将跨直流刺激 (tDCS) 与工作记忆训练 (WMT) 结合起来,可以促进长期的认知收益. 这项研究发现,在tDCS和WMT会话后,大脑活动和P300反应的持续神经改善.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 神经调节是一种神经调节.
背景情况:
- 通过结合跨直流刺激 (tDCS) 和工作记忆训练 (WMT) 实现持续认知增强的基础的神经机制尚未完全理解.
- 调查长期的神经生理变化对于优化大脑刺激协议至关重要.
研究的目的:
- 探索多会话阳极高清 (HD) -tDCS与工作记忆训练 (WMT) 结合的持久神经生理效应.
- 为了检查HD-tDCS在左背侧前额皮质 (dlPFC) 上如何影响工作记忆任务期间的大脑活动.
主要方法:
- 34名健康的年轻人参加了一项随机的,假的受控研究.
- 参与者每天接受10次主动或虚假的HD-tDCS,并与具有挑战性的WMT协议配对.
- 与任务相关的脑电图 (EEG) 在测试前,测试后 (训练后1天) 和随访 (训练后3周) 评估期间被记录下来.
主要成果:
- 多会话HD-tDCS显著放大了WMT的行为益处.
- 活跃的tDCS组在训练后表现出增强的,α,β和马振荡.
- 在活动组中观察到P300反应的显著增加,这是最后一次会议后的三周.
结论:
- 在多次会议WMT期间对左dlPFC应用的阳极HD-tDCS增强了行为改善.
- 这种综合方法促进了与工作记忆相关的持续神经效率.
相关概念视频
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...


