生物工程小麦阿拉比诺基兰 - 促进下一代益生菌向与健康相关的肠道微生物
Emmanuel N Njoku1, Walid Mottawea1,2, Hebatoallah Hassan1
1NuGut Research Platform, School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Plant foods for human nutrition (Dordrecht, Netherlands)
|November 3, 2023
概括
改性小麦阿拉比诺基兰 (AX) 纤维显示出增强的益生菌潜力. 具有特定结构的低质量AX显著促进了有益的肠道细菌的生长和短链脂肪酸的产生,这表明它们可以作为下一代益生菌使用.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 食纤维,特别是益生菌纤维,对于肠道微生物群调节至关重要.
- 像小麦阿拉比诺基兰 (AX) 这样的纤维的结构异质性会影响微生物利用和健康益处.
- 了解AX结构-活性关系是开发向益生菌的关键.
研究的目的:
- 研究小麦AX的质量和化学结构如何影响*Faecalibacterium prausnitzii*和*Lacticaseibacillus rhamnosus*的生长和代谢.
- 为了评估修改后的AX结构的前生物潜力.
- 为了确定最佳的AX修改来增强有益的肠道细菌.
主要方法:
- 小麦AX被分成低,中,高质 (LAX,MAX,HAX).
- 在AX样本中进行了酶性修改,以改变西洛斯单元替代模式.
- 微生物生长和短链脂肪酸 (SCFA) 产量由*F.prausnitzii*和*L.rhamnosus*使用修改的AX基质进行测量.
主要成果:
- 经过修改的AX样本与未经修改的AX相比,通常表现出更高的益生菌评分.
- 低质量AX (LAX),特别是双替代的西洛斯单元,显示出最高的益生菌潜力和SCFA产量.
- 单个或双重替代的AX始终促进了L. rhamnosus*的生长,而所有阿拉比诺斯被删除的AX优先影响了F. prausnitzii*.
结论:
- 生物工程小麦AX,特别是具有特定替代模式的LAX,具有作为下一代益生菌的巨大潜力.
- 定制AX结构可以选择性地增强关键的与健康相关的肠道微生物的生长和代谢活动.
- 这些发现为设计针对肠道健康的有针对性的益生菌干预措施提供了基础.
关键词:
酵素生物工程是一种生物工程.便细菌 (Faecalibacterium prausnitzii) 是一种可以引起便的细菌.与健康相关的微生物乳糖菌cillus rhamnosus LGG 乳糖菌cillus rhamnosus LGG 乳糖菌cillus rhamnosus 乳糖菌cillus rhamnosus 乳糖菌cillus rhamnosus 乳糖菌cillus rhamnosus 乳糖菌cillus rhamnosus 乳糖菌cillus rhamnosus 乳糖菌cillus rhamnosus 乳糖菌cillus rhamnosus益生菌效应 益生菌效应小麦阿拉比诺克西兰.相关概念视频
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