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Updated: Jul 11, 2025

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通过DNA编码的图书馆,发现了近距离诱导的小分子

Jeremy W Mason1,2, Yuen Ting Chow1,3, Liam Hudson1,2

  • 1Chemical Biology and Therapeutics Science, Broad Institute, Cambridge, MA, USA.

Nature chemical biology
|November 3, 2023
PubMed
概括

研究人员使用DNA编码的库开发了一个新的平台,以发现连接蛋白质的小分子. 这种方法成功地确定了诱导蛋白质-蛋白质相互作用的化合物,从而导致向蛋白质降解.

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Labeling DNA Probes03:31

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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