在第一次初级乳腺癌治疗后,发展逆侧乳腺癌的危险因素
Maryam Avatefi1, Fatemeh HadavandSiri1, Seyed Saeed Hashemi Nazari2
1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer reports (Hoboken, N.J.)
|November 3, 2023
概括
被诊断为乳腺癌的老年女性患上逆侧乳腺癌的风险较低. 这一发现凸显了针对乳腺癌幸存者的量身定制监测策略的必要性.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 乳腺癌 (BC) 是全球女性的主要癌症.
- 原发性乳腺癌 (PBC) 的生存率增加导致 contralateral乳腺癌 (CBC) 病例的增加.
- 了解CBC的风险因素对于改善患者的治疗结果至关重要.
研究的目的:
- 调查无病区间 (DFI),风险因素和PBC特征对CBC发育的影响.
- 为了确定与CBC进展相关的特定患者人口统计和临床特征.
- 提供对患有二次恶性瘤风险的乳腺癌幸存者的管理的见解.
主要方法:
- 在2000年至2020年期间,对5003名被诊断为乳腺癌的妇女进行了回顾性分析.
- 纳入标准:145名CBC患者 (PBC诊断后≥6个月) 和4858名PBC幸存者.
- 使用Kaplan-Meier方法和Cox比例危险回归模型进行统计分析.
主要成果:
- 从PBC到CBC的中位时间为3.92年;5年的DFI为97%.
- 在CBC患者中,雌激素受体阳性 (ER+),孕激素受体阳性 (PR+) 和HER2阳性 (HER2+) 亚型是常见的.
- 侵入性导管癌 (IDC) 是主要的组织学.
- 辅助化疗和放射治疗被广泛使用.
- 60岁及以上的女性与CBC发育有负面关联.
结论:
- 这项研究是首次检查伊朗PBC幸存者的CBC和DFI风险因素.
- 高龄,特别是60岁以上的年龄,与患上CBC的风险降低有关.
- 对老年乳腺癌幸存者的密切监测对于早期发现CBC至关重要.
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