一个普尔金尼细胞到抛臂核的通路使大脑对前脑产生广泛的大脑小脑影响
Christopher H Chen1,2, Leannah N Newman1, Amanda P Stark1
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Nature neuroscience
|November 3, 2023
概括
小脑通过新发现的普尔金耶细胞 (PC) 到双臂核 (PBN) 途径直接调节前脑的情绪和情感功能. 这条路径绕过了传统的深小脑核,影响了焦虑和厌恶.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 大脑小叶的功能
背景情况:
- 小脑,传统上以运动控制而闻名,越来越多地被认为是其在情绪调节,焦虑和情绪影响方面的作用.
- 通过深层小脑核的经典小脑输出并没有直接投射到涉及情绪处理的前脑区域.
研究的目的:
- 研究小脑通过哪些直接的神经通路影响前脑的情绪调节.
- 识别特定的小脑细胞类型及其涉及非运动功能的投射.
主要方法:
- 光遗传抑制小脑Purkinje细胞 (PC) 发射.
- 从小脑追踪神经元投射到前脑区域.
- 目标神经元的分子概况.
- 评估行为反应 (厌恶性).
主要成果:
- 抑制PC发射迅速激发前脑参与情绪的区域 (杏仁体,基底前脑,隔膜).
- 个人电脑直接抑制双臂核 (PBN) 神经元,这些神经元向前脑广泛发射.
- 破坏PC-PBN通路导致厌恶行为,并影响许多前脑区域.
- 分子分析显示,PCs抑制了各种PBN神经元类型,控制非运动行为.
结论:
- PC-PBN通路为小脑提供了直接的途径,以调节与情绪和情感相关的前脑活动.
- 这条途径是理解小脑对情绪障碍的贡献的关键基质,特别是与后虫损伤相关的情绪障碍.
相关概念视频
Cerebellum: Anatomical Regions
1.7K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
1.7K
Major Somatic Sensory Pathways
986
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
986
Diencephalon: Thalamus and Information Relay
1.6K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.6K
Overview of Somatic Sensory Pathways
4.5K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
4.5K
Brainstem
2.1K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
2.1K
Indirect Motor Pathways
1.5K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.5K


