精油及其纳米配方用于乳腺癌治疗
Muhammed Ashiq Thalappil1, Priya Singh2, Alessandra Carcereri de Prati1
1Department of Neuroscience, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, Verona, Italy.
Phytotherapy research : PTR
|November 3, 2023
概括
精油 (EO) 对乳腺癌 (BC) 具有抗癌潜力. 纳米技术增强了EO输送,克服了改善BC治疗和降低毒性的局限性.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
背景情况:
- 乳腺癌 (BC) 是全球领先的癌症,目前的治疗方法面临毒性,化学抵抗和复发等局限性.
- 植物化学物质,特别是精油 (EO),由于其安全性和瘤向能力,正在成为有希望的抗癌剂.
- 由于易挥发性,不稳定性和溶解性差,EO的临床应用受到阻碍,需要先进的输送系统.
研究的目的:
- 审查精油及其成分对乳腺癌 (BC) 模型的抗癌作用.
- 探索纳米技术在提高乳腺癌治疗EO的疗效方面的作用.
- 概述了在BC对EO的体外和体内研究的当前知识.
主要方法:
- 关于精油 (EO) 和乳腺癌 (BC) 的研究文献综述.
- 使用的关键词:"乳腺癌中的抗增殖精油"",乳腺癌中的精油抗癌活性"",乳腺癌中的精油细胞毒性".
- 搜索的数据库:PubMed和科学直接.
主要成果:
- 在临床前模型中,精油 (EO) 在乳腺癌 (BC) 上表现出显著的抗增殖和细胞毒性作用.
- 基于纳米技术的传递系统有效地封装了EO,提高了它们的稳定性,溶解性和生物可用性.
- 在各种BC模型中,封装的EO显示出增强的抗癌活性和降低的毒性.
结论:
- 精油 (EO) 是乳腺癌 (BC) 的可行的天然治疗策略.
- 纳米技术对于克服EO的交付挑战至关重要,释放它们的全部治疗潜力.
- 对纳米配制的EO的进一步研究可能会导致新的,更安全,更有效的乳腺癌治疗方法.
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