表观遗传衰老和骨质疏松症的因果关系:双向的门德尔随机化研究
Xinyu Liang1, Wei Shi1, Xinglong Zhang2
1Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China.
BMC medical genomics
|November 3, 2023
概括
这项研究调查了表观遗传年龄和骨质疏松症之间的联系. 虽然从表观遗传年龄到骨质疏松症之间没有明确的因果关系,但较低的骨密度可能会加速表观遗传衰老,特别是GrimAge.
科学领域:
- 生物医学科学 生物医学科学
- 遗传学 是一个遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 长期衰老和骨质疏松症之间的确立联系得到了充分证实.
- 生理 (表观遗传) 年龄和骨质疏松症之间的关系在很大程度上仍未被探索.
- 表观遗传时钟提供了一种与时间年龄不同的生物衰老指标.
研究的目的:
- 调查表观遗传钟和骨质疏松症之间的双向因果关系.
- 使用孟德尔随机化来评估表观遗传年龄和骨矿物质密度之间的因果关系.
- 探索特定表观遗传时钟 (GrimAge,Hannum,PhenoAge,HorvathAge) 和骨质疏松症之间的潜在联系.
主要方法:
- 采用双向门德尔随机化 (MR) 研究设计.
- 使用与表观遗传钟 (GrimAge,Hannum,PhenoAge,HorvathAge) 相关的单核酸多态 (SNP) 作为仪器变量.
- 评估因果关系使用逆方差加权和其他MR方法来测量骨矿物密度 (大腿部,腰椎,前臂).
主要成果:
- 从表观遗传年龄 (GrimAge,Hannum,PhenoAge,HorvathAge) 到大腿部部,腰椎或前臂的骨矿物质密度之间没有明显的因果关系.
- 反向MR分析显示,腰椎骨矿物质密度对GrimAge (OR=0.692,95%CI=0.538-0.890,p=0.004) 有显著的因果关系.
- 研究结果表明,腰椎骨密度降低可能会加速GrimAge表观遗传时钟.
结论:
- 该研究发现,表观遗传年龄和整体骨质疏松症之间没有显著的双向因果关系.
- 腰椎骨密度的减少似乎加速了GrimAge表观遗传时钟.
- 部分证据支持表观遗传年龄和骨质疏松症之间的双向因果关系,特别是关于GrimAge和腰椎骨密度.
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