在学龄儿童中,右半球能否补偿左半球,而左半球有较大的左中间骨囊?
Wenjian Zheng1,2, Xueyi Guan1, Zheng Lu1
1Department of Pediatric Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, PR China.
BMC pediatrics
|November 3, 2023
概括
患有大左中甲状腺囊 (MFAC) 的儿童表现出注意力和记忆力受损. 大脑网络分析显示功能连接性降低,健康半球的补偿性神经可塑性有限.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 认知神经科学 认知神经科学
背景情况:
- 大的左中甲状腺囊 (MFACs) 可以影响儿童的神经发育.
- 评估认知功能和大脑网络的改变对于理解MFACs的影响至关重要.
研究的目的:
- 评估学龄儿童的认知功能和大脑网络神经可塑性,这些儿童有较大的左侧MFACs.
- 研究这些患者的认知缺陷和功能连接性改变之间的关系.
主要方法:
- 在11名MFAC患者和22名对照患者 (6-14岁) 中,使用中枢神经系统生命体征 (CNS VS) 进行认知评估.
- 休息状态功能磁共振成像 (rs-fMRI) 用于分析功能连接 (FC) 和局部相关性 (LCOR).
- 患者和对照组之间的认知数据和FC的比较,与相关性分析.
主要成果:
- 与对照组相比,MFAC患者的注意力和记忆功能明显较差 (p < 0.05).
- 在MFAC患者中观察到较低的LCOR和减少的双边额叶和叶FC (分别p-FDR<0.001和p-FDR<0.05).
- 改变的FC,特别是在右叶和左叶之间,与认知得分相关,而囊大小与反应时间的相关性很弱.
结论:
- 较大的左侧MFAC与学龄儿童注意力和记忆领域的显著缺陷有关.
- 健康半球中的神经可塑性和补偿机制在患有MFAC的儿童中似乎有限.
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