局部性前列腺癌治疗前患者报告的结果:各国之间是否存在差异? 来自真北全球登记处的数据
O Garin1,2,3, C Kowalski4, V Zamora1,2,5
1Health Services Research Group, IMIM (Hospital del Mar Medical Research Institute) Barcelona Biomedical Research Park, Office 144, Doctor Aiguader 88, Barcelona, 08003, Spain.
BMC urology
|November 3, 2023
概括
针对局部性前列腺癌的患者报告结果在不同国家之间存在差异,特别是在性健康方面. 在诊断时实施PRO测量对于个性化治疗评估至关重要.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医疗保健服务研究 医疗服务研究
背景情况:
- 针对局部性前列腺癌的患者报告结果 (PROs) 在各国似乎相似.
- 这表明,无论区域卫生系统,文化因素或患者偏好如何,都可以推治疗.
研究的目的:
- 为了比较不同国际地区局部性前列腺癌诊断时患者报告的结果 (PROs).
- 识别可能影响治疗建议的PRO变异.
主要方法:
- 对13483名被诊断患有局部或局部晚期前列腺癌的男性的EPIC-26数据的分析 (2017年1月至2019年9月).
- 跨越七个地区 (澳大利亚/新西兰,加拿大,中欧,英国,意大利,西班牙,美国) 的前性,多中心国际队列研究.
- 对EPIC-26域得分和不同地区的具体项目进行比较,分层按治疗 (急性前列腺切除术,放射治疗,支臂治疗,主动监测) 划分.
主要成果:
- 在治疗前,在不同国家中观察到PRO域模式的显著变化.
- 性领域表现出最严重的损害和最大的变化,在国家内部和国家之间.
- 尿失禁,肠道和荷尔蒙领域显示高得分 (更好的结果) 和跨区域和治疗方法的一致性.
结论:
- 针对局部性前列腺癌的治疗前的PROs显示,在激进前列腺切除术,放射治疗,支架治疗和积极监测方面,国家间的差异大多是很小的.
- 尿失禁和肠道领域的高分数可能会限制它们在评估治疗效果方面的有用性.
- 国家特异性,特别是在性领域,强调了PRO测量在诊断和治疗评估时的重要性.
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