概括
对真菌过敏的过敏免疫疗法 (AIT) 由于提取质量和有限的数据而复杂. Alternaria alternata免疫疗法显示有效,但不建议用于诊断或治疗的真菌混合物.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 菌类学 菌类学是指菌类学.
背景情况:
- 使用真菌提取物的过敏免疫疗法 (AIT) 存在挑战,原因是大量的空气传播真菌物种,有限的暴露数据和可变的提取物质量.
- 对真菌AIT疗效的受控研究很少,Alternaria是一个值得注意的例外.
研究的目的:
- 审查真菌在过敏呼吸道疾病中的作用.
- 评估支持AIT对真菌引起的疾病的证据.
主要方法:
- 使用PubMed,教科书和关于真菌免疫治疗的现有文章进行了全面的文献搜索.
- 此外,还审查了来自初级来源的引用.
主要成果:
- 确定了9项关于Alternaria (或Alt a1) 的研究和2项关于Cladosporium herbarum免疫疗法的研究.
- 通过高质量的提取物和适当的剂量证明了Alternaria AIT的有效性,与其他吸入性过敏原相比.
- 克拉多斯波里亚AIT显示出潜力,但受到系统反应的限制;缺乏过敏真菌鼻炎AIT的证据.
结论:
- 性免疫疗法应主要集中在Alternaria alternata和潜在的Cladosporium herbarum上.
- 只有当特定的真菌暴露,相关症状和强烈的过敏原提取物可用时,才考虑真菌AIT.
- 不建议用于诊断或治疗的真菌 (菌) 混合物.
更多相关视频
10:06Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways
Published on: December 13, 2024
408
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
10.0K
相关概念视频
Drugs Used in Lower Respiratory Disorders: Overview
455
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
455
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
310
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
310
Allergic Reactions
27.6K
Overview
27.6K
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
273
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
273
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Asthma: Pathogenesis and Management
420
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
420
