母乳血清生物标志物与胎儿先天性心脏病之间的关联分析
Hong Jiang1, Yuan Lin2, Xinqin He3
1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, 350005 Fuzhou, Fujian, China; Department of Obstetrics and Gynecology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, 350212 Fuzhou, Fujian, China. jianghong53411@163.com.
The heart surgery forum
|November 3, 2023
概括
第二个三个月的母体血清生物标志物,如α-fetoprotein (AFP) 和β-人类胆性腺激素 (HCG),可以表明胎儿先天性心脏病 (CHD). 较低的非结合性醇3 (uE3) 水平也与心脏病风险增加相关.
科学领域:
- 在产前查.
- 孕产妇血清标志物分析
- 先天性心脏病诊断 诊断先天性心脏病
背景情况:
- 在产前诊断中,先天性心脏病 (CHD) 是一个重大问题.
- 在第二个三个月的母体血清查通常针对染色体异常,如唐氏综合征.
- 在低风险人群中确定冠心病的额外标志物可以提高产前评估.
研究的目的:
- 为了研究母体血清生物标志物α-fetoprotein (AFP),β-人类胆性淋巴激素 (HCG) 和未结合的3 (uE3) 与胎儿心血管疾病之间的关联.
- 评估这些生物标志物在第二个三个月的低风险怀孕中查冠心病的有用性.
主要方法:
- 一项病例控制研究,涉及109名被诊断患有心脏病的胎儿和344名对照.
- 孕妇血清中hcg,afp和ue3的水平在第二个三个月内被测量.
- 包括后勤回归在内的统计分析被用来确定与胎儿心脏病的关联.
主要成果:
- 升高的HCG和AFP水平 (中位数[MoM]≥85%量子) 和降低的UE3 (MoM≤15%量子) 与胎儿心血管疾病有显著的相关性.
- 多变量分析确定高的HCGMoM和AFPMoM,或低的UE3MoM,作为心血管疾病的独立预测因素.
- 胎儿心血管疾病的风险随着这些生物标志物模式中的一个或多个存在而增加.
结论:
- 第二个三个月的母体血清生物标志物 (AFP,HCG,UE3) 显示为胎儿心脏病查的潜在指标.
- 这些标记可能有助于识别患心血管疾病风险的怀孕,特别是那些没有发现染色体缺陷的怀孕.
- 进一步的研究可以完善这些生物标志物的使用,以对产前综合性心血管疾病进行评估.
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