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骨肌肉DNA甲基化:运动和艾滋病毒的影响

Catherine M Jankowski¹, Iain R Konigsberg², Melissa P Wilson³

¹College of Nursing, University of Colorado Anschutz Medical Campus, Colorado, Aurora, USA.

|November 3, 2023

概括

运动训练对艾滋病毒 (PWH) 感染者和对照者的骨肌肉DNA甲基化有影响. 艾滋病毒状态对表观遗传变化的影响比运动更大,对表观遗传衰老加速没有显著影响.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
骨肌肉生物学骨肌肉生物学
艾滋病毒研究艾滋病毒研究

背景情况:

衰老,艾滋病毒感染和抗逆转录病毒治疗改变了细胞表观遗传特征.
在HIV中加速表观遗传衰老可能导致早期脆弱.
运动可以诱导骨肌肉的表观遗传修饰,可能减轻脆弱性.

研究的目的:

为了研究24周运动训练对骨肌肉DNA甲基化和表观遗传衰老加速 (EAA) 在老年,病毒抑制的艾滋病毒 (PWH) 患者和对照者的影响.
在基线检查EAA和身体功能之间的关联.

主要方法:

在PWH (n=12) 和对照组 (n=18) 在24周有氧和阻力运动前后比较了PWH (n=12) 和对照组 (n=18) 的广侧面肌肉中的DNA甲基化概况和EAA.
分析了差异甲基化位 (DMP) 和它们与身体功能的关联.

主要成果:

在基线确定了983名DMP,在培训后确定了237名DMP.
艾滋病毒血清状况对骨肌肉甲基化的影响比运动训练更为明显.
在PWH和对照组之间,基线EAA没有显著差异,而运动并没有显著改变EAA. EAA与身体功能没有相关性.

结论:

初步发现表明,骨肌肉对运动的反应具有针对HIV的表观遗传适应.
需要采用转录组分析进行更大规模的研究来确认.

关键词:

通过DNA甲基化.艾滋病病毒艾滋病病毒艾滋病病毒老化的老化衰老的老化这是表观遗传学.表观遗传时钟的时间表.运动训练运动训练运动训练这是骨肌肉的骨架肌肉.

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