在轻度阿尔茨海默病患者的睡眠障碍中改变了局部和远程功能连接
Lei Wang1, Rui Zhu1, Xiao Zhou2
1Department of Neurology, Beijing Geriatric Hospital, Beijing, China.
Frontiers in aging neuroscience
|November 3, 2023
概括
轻度阿尔茨海默病患者有睡眠障碍,表现出局部和远程大脑连接受损,特别是在感官和视觉网络. 这些干扰可能会导致认知能力下降,这表明睡眠质量会影响阿尔茨海默病的进展.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 认知神经学 认知神经学
背景情况:
- 睡眠障碍在阿尔茨海默病 (AD) 中很常见.
- 睡眠障碍对轻度阿尔茨海默病患者大脑功能连接的影响尚不清楚.
- 了解这些变化对于管理认知衰退至关重要.
研究的目的:
- 在轻度阿尔茨海默症患者 (ADSD) 与没有 (ADNSD) 睡眠障碍的患者中调查局部和远程功能连接性差异.
- 为了确定受早期AD睡眠障碍影响的特定大脑区域和网络.
- 探索ADSD中功能连接性改变和认知障碍之间的关系.
主要方法:
- 招募了38名患有睡眠障碍 (ADSD) 的轻度AD患者和21名没有睡眠障碍 (ADNSD) 的患者.
- 使用3.0特斯拉MRI进行功能连接分析.
- 通过基于种子的分析,评估了具有静态和动态区域同质性 (ReHo) 的本地连接性和远程连接性.
主要成果:
- 与ADNSD患者相比,ADSD患者在左后中心和右中显示出静态ReHo降低.
- 在ADSD患者的左后中心环中观察到增加的动态ReHo.
- 在ADSD患者中,在左后中心和左骨/左骨之间发现了减少的远程功能连接.
结论:
- 患有睡眠障碍的轻度AD患者在本地和远程功能连接方面表现出显著的损害.
- 这些连接缺陷,特别是在主要的感官和视觉网络中,可能是睡眠障碍在促进AD认知障碍中的作用的基础.
- 睡眠障碍可能会改变AD中大脑网络损伤的时间进展,需要进一步调查.
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