乳酸脱酶预测了在接受阿兹武丁治疗的COVID-19患者的疾病进展结果
Manyun Mao1,2,3,4,5, Yating Dian1,2,3,4,5, Yuming Sun2,3,4,5,6
1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Frontiers in cellular and infection microbiology
|November 3, 2023
概括
高乳酸脱酶 (LDH) 水平表明,用阿兹丁治疗的COVID-19患者的预后更差. 这一发现有助于预测接受这种抗病毒治疗的患者的疾病进展.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 阿兹丁是中国批准的COVID-19治疗方法.
- 乳酸脱酶 (LDH) 的升高与COVID-19的严重程度有关.
- 尚不清楚LDH对阿兹武丁治疗结果的影响.
研究的目的:
- 为了研究高LDH水平和COVID-19患者治疗Azvudine的疾病进展之间的关联.
- 分析与LDH水平相关的临床特征和治疗策略.
主要方法:
- 对351名住院的COVID-19患者进行了回顾性队列研究,这些患者接受了Azvudine治疗.
- 收集的数据包括临床特征,治疗和预后.
- 考克斯的比例危险模型用于评估高LDH水平的影响.
主要成果:
- 患有高LDH水平的患者表现出炎症标志物增加和机械通风率更高.
- 高的LDH与明显更糟糕的复合疾病进展结果有关 (2.5%与0%恶化/死亡).
- 高LDH水平是不利结果的独立预测因素 (aHR=5.27).
结论:
- 高LDH水平是接受阿兹武丁的COVID-19患者疾病进展恶化的重要预测因素.
- 低低血压水平可以帮助分层风险,并为这些患者制定治疗策略.
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