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皮肤与自闭症谱系障碍之间的联系

Mao-Qiang Man^1,2,3, Shuyun Yang⁴, Theodora M Mauro^2,3

¹Dermatology Hospital, Southern Medical University, Guangzhou, China.

Frontiers in psychiatry

|November 3, 2023

概括

自闭症谱系障碍 (ASD) 可能与皮肤炎症和功能障碍有关. 治疗皮肤疾病和改善表皮功能显示出管理ASD症状的潜力.

科学领域:

神经学神经学
皮肤病学皮肤病学
免疫学免疫学免疫学

背景情况:

自闭症谱系障碍 (ASD) 是一种常见的神经疾病,具有复杂的病因.
有证据表明皮肤炎症和ASD之间存在联系,炎症性皮肤病患者的患病率更高.
最近的研究表明,表皮功能障碍与ASD之间存在联系.

研究的目的:

总结当前关于皮肤病与ASD之间的关联的证据.
探索皮肤炎症和表皮功能障碍在ASD中的致病作用.

主要方法:

审查当前的科学文献和研究.
分析来自ASD小鼠模型的发现.
检查患有自闭症儿童的临床观察结果.

主要成果:

患有自闭症的个体患有炎症性皮肤病的患病率更高.
患有自闭症的小鼠模型表现出表皮功能障碍和皮肤和大脑中炎症前导细胞因子的增加.
患有自闭症的儿童表现出表皮功能改变,改善缓解了一些症状.

结论:

皮肤功能障碍似乎在ASD中起着病原性作用.
改善表皮功能或治疗炎症性皮肤病可能为ASD提供替代管理策略.

关键词:

自闭症自闭症是什么皮肤上的透性屏障障补充水分补充水分补充水分这是一种炎症炎症炎症炎症.层层的角质层 (stratum corneum) 是一个层.

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