在医疗保健提供者中ChAdOx1 (Covishield) 增强剂量的免疫性:一项前后研究
Trupti Meher1, Subrat K Pradhan1, Shankar P Hatei2
1Community Medicine, Veer Surendra Sai Institute of Medical Sciences and Research, Sambalpur, IND.
Cureus
|November 3, 2023
概括
一种COVID-19的助推剂量显著增加了医疗保健工作者中的抗体水平,诱导血清转换并增强了对SARS-CoV-2的免疫力. 鉴于初始疫苗接种的效果逐渐减弱,这种重要的免疫反应至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 由于高暴露风险,医疗保健工作者优先接种COVID-19疫苗.
- 建议使用ChAdOx1 (Covishield) 疫苗的第三次增强剂量,以加强对SARS-CoV-2的保护.
- 关于这种助推剂对抗体水平的影响的数据有限.
研究的目的:
- 评估免疫反应,特别是免疫球蛋白-G (IgG) 水平,在ChAdOx1 (Covishield) COVID-19增强剂后.
- 为了评估医疗保健提供者在初级疫苗接种后免疫力下降的情况下增强剂的有效性.
主要方法:
- 一项涉及132名印度医疗保健提供者的前后研究.
- 采集的血液样本预增剂和一个月后增剂测量IgG抗体对SARS-CoV-2尖端蛋白受体结合域.
- 化学发光微粒免疫试验用于IgG水平的确定.
主要成果:
- 29%的参与者在补充剂之前缺乏可检测的抗体.
- 所有参与者在增强剂后都实现了血清转化.
- 在增剂后一个月观察到抗体水平的统计显著增加 (p<0.0001).
结论:
- 提升剂量ChAdOx1 (Covishield) 有效地诱导卫生保健工作者的血清转化.
- 助推剂的使用显著提高了抗体水平,增强了对COVID-19的免疫力.
- 这对于保持保护至关重要,因为对初级疫苗接种的免疫力减弱.
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