低血红蛋白活性与"明显"的异常性心房有关
Youmei Shen1, Guodong Ma2, Min Sun2
1Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, China.
International journal of cardiology. Heart & vasculature
|November 3, 2023
概括
低宁活性与明显的异常性心房动 (AF) 有关. 这项研究发现,氨酸- ангиотензин-阿尔多素系统 (RAAS) 活性与切除后的AF复发之间没有关联.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 内部医学 内部医学
背景情况:
- 氨酸- ангиотензин- алдостерон系统 (RAAS) 涉及到心房动 (AF).
- 在异常性AF中早期RAAS失调及其对切除后复发的影响尚不清楚.
研究的目的:
- 与对照人群相比,研究RAAS激活在明显异常性AF患者中的情况.
- 为了确定RAAS和AF在导管切除后复发之间的关系.
主要方法:
- 一项前性,病例对照研究,将51名患有异常性AF的患者与91名患有 Paroxysmal supraventricular tachycardia (PSVT) 的患者进行比较.
- 主要结局:RAAS激活 (血蛋白活性 - PRA).
- 二次结果:在消去后的1年AF复发.
主要成果:
- 与PSVT对照组相比,更高比例的AF患者具有较低的PRA (<1 ng/ml/h) (25.5%与7.7%,P=0.003).
- 较低的PRA (<1 ng/ml/h) 独立地与异常性AF诊断相关 (OR 3.98,P=0.024).
- 在AF复发和没有AF复发的患者之间,在RAAS组件中没有发现显著的差异.
结论:
- 低宁活性与明显异常性心房的诊断有关,特别是 Paroxysmal AF.
- 在导管切除后,RAAS激活似乎不是AF复发的显著预测因素.
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