糖尿病病的精准医学:以实践经验为框架的叙事审查
Mallory L Downie1, Arlene Desjarlais2, Nancy Verdin2
1McGill University Health Center Research Institute, Montreal, QC, Canada.
Canadian journal of kidney health and disease
|November 3, 2023
概括
精准医学,包括基因组学,代谢学和蛋白质学,为治疗糖尿病病 (DKD) 提供了潜力. 需要进一步的研究来将这些方法纳入临床实践,以更好地诊断和治疗DKD.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 遗传学 遗传学 是一个
- 代谢学 代谢学 代谢学
- 蛋白质组学是指蛋白质组学.
- 精准医学是一门精准的医学.
背景情况:
- 糖尿病病 (DKD) 是慢性病 (CKD) 和衰竭的主要原因.
- DKD是复杂而异质的,患者的结果各不相同.
- 现有的治疗方法旨在减缓CKD的进展,但正在出现个性化的方法.
研究的目的:
- 审查用于DKD管理的精准医学策略.
- 探索基因组学,代谢学和蛋白质组学在糖尿病和DKD中的作用.
- 将患者和护理人员的生活经验纳入审查中.
主要方法:
- 现有文献的叙述性审查.
- 在MEDLINE和谷歌学者中进行的搜索.
- 在DKD中对精准医学研究的批判性评估,以患者的观点为依据.
主要成果:
- 基因组学有助于诊断单基因糖尿病并识别与DKD相关的基因,尽管临床翻译滞后.
- 代谢学和蛋白质学在改善DKD诊断,识别致病途径,预测CKD进展和治疗反应方面表现有前途.
- 对于DKD发病和进展的生物标志物存在,但需要与当前的风险预测工具进行整合.
结论:
- 精准医学方法如基因组学,代谢学和蛋白质学对DKD的诊断,预后和治疗具有前途.
- 目前来自高质量的研究和临床试验的证据支持精准医学改善DKD结果是有限的.
- 进一步的研究对于验证和实施精准医学在DKD管理中至关重要.
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