肺切除后持续咳的轨迹和危险因素:一个前性的两中心研究
Xuefeng Sun1,2,3, Zihua Lan2,4, Shaopeng Li1,2,5
1The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Thoracic cancer
|November 3, 2023
概括
肺癌手术后持续咳显著影响25%的患者的生活质量. 长时间的麻醉和酸倒流是这种情况的关键危险因素.
科学领域:
- 胸部外科手术 胸部外科手术
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
背景情况:
- 持续咳是肺癌手术后的一个常见并发症.
- 这项研究调查了咳的轨迹及其对生活质量 (QOL) 的影响.
- 鉴定肺切除 (CAP) 后持续咳的危险因素对于患者的康复至关重要.
研究的目的:
- 为了检查肺切除后持续咳症状的时间进程.
- 评估持续咳对患者生活质量的影响.
- 为了确定与手术后持续咳相关的独立风险因素.
主要方法:
- 对506名为肺瘤进行肺切除的患者进行前性观察性研究.
- 在多个时间点使用VAS,CSS和LCQ-MC评估咳症状和QOL.
- 用单变量和多变量逻辑回归分析来确定风险因素.
主要成果:
- 持续咳 (CAP) 的发生率为25.69% (130/506名患者).
- 持久性CAP患者报告QOL显著降低,VAS高,CSS得分高达手术后6个月.
- 长时间麻醉 (>156分钟) 和胃食道逆流 (GER) 被确定为独立的危险因素 (分别为OR1.847和3.870).
结论:
- 持续的咳显著降低了肺切除后长期的QOL.
- 长时间的麻醉时间和术后的GER是产生持续咳的重要风险因素.
- 这些发现凸显了管理麻醉时间和GER以减轻持续咳的必要性.
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