IGF-1 抑制了巨细胞中棕酸诱导的线粒体亡
Wanying Tang1, Ming Zhang2, Yu Wang2
1Department of Physiology, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, University of South China, Hengyang, Hunan 421001, P.R. China.
Molecular medicine reports
|November 3, 2023
概括
胰岛素生长因子-1 (IGF-1) 通过抑制线粒体亡,保护巨细胞免受脂肪酸损伤. 这项研究揭示了IGF-1的存在.
科学领域:
- 免疫代谢过程中的免疫代谢.
- 细胞生物学 细胞生物学
- 内分泌学 在内分泌学.
背景情况:
- 胰岛素生长因子-1 (IGF-1) 是一个关键的内分泌调节剂.
- IGF-1可能会保护巨细胞免受免疫代谢压力.
- IGF-1对脂肪酸诱导的巨细胞损伤的影响尚不清楚.
研究的目的:
- 为了研究IGF-1对棕酸 (PA) 诱导的巨细胞损伤的保护作用.
- 阐明IGF-1的保护作用背后的机制.
主要方法:
- THP-1细胞分化为巨细胞,并用PA +/- IGF-1进行治疗.
- 通过CCK-8试验,流细胞测量,霍克斯特染色和西部涂抹来评估亡.
- 用JC-1染色,ROS检测,免疫光和西部斑点测试来评估线粒体损伤和线粒体活化.
主要成果:
- IGF-1显著增加了巨细胞的存活率,并通过线粒体通路抑制了亡.
- 保护IGF-1免受PA诱导的线粒体损伤.
- 通过PTEN诱导的假定激酶1 (PINK1) /帕金因诱导的PA诱导的线粒细胞衰变被IGF-1逆转.
结论:
- IGF-1在巨细胞中显示出对棕酸诱导的线粒体亡的保护作用.
- IGF-1可能为脂毒性治疗提供治疗策略.
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