亲密肉瘤的免疫微环境:具有潜在治疗意义的适应性免疫抵抗
Jacqueline E Birkness-Gartman1, Dwayne L Thomas2, Logan L Engle2
1Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, US.
American journal of clinical pathology
|November 3, 2023
概括
内体瘤表现出一个活跃的免疫微环境,具有编程细胞死亡1联体1 (PD-L1) 表达. 这表明免疫疗法可能是对这些罕见的侵袭性瘤的可行的治疗方法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 内体瘤是一种罕见的,来自大血管的侵袭性癌症.
- 了解瘤免疫微环境对于开发新型治疗策略至关重要.
研究的目的:
- 为了描述亲密肉瘤的免疫微环境.
- 为了研究编程细胞死亡1联体1 (PD-L1) 和其他免疫标记物的表达.
- 探索免疫细胞透,PD-L1表达和患者结果之间的潜在相关性.
主要方法:
- 在7名患者的17个内肉瘤样本上进行了免疫组织化学检查.
- 分析的标记物包括PD-L1,CD45,CD8,CD4,FOXP3,CD20,CD68和LAG3.3等.
- 使用图像分析软件量化免疫细胞密度和PD-L1表达.
主要成果:
- 所有亲密的肉瘤都显示出免疫细胞透,密度各不相同.
- 在很大一部分病例中,在瘤和免疫细胞上检测到PD-L1表达.
- 较高的CD8+,FOXP3+和LAG3+细胞密度与PD-L1表达和其他标记物相关,表明了自适应性免疫反应. 一名长期存活的患者显示出高免疫细胞密度和PD-L1表达.
结论:
- 内部肉瘤具有具有适应性PD-L1表达模式的活跃瘤微环境.
- 这些发现支持免疫疗法在治疗亲密肉瘤方面的潜在疗效.
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