血液中含量和妊娠期糖尿病:系统性审查和元分析
1Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
概括
高血水平与孕妇妊娠期糖尿病 (GDM) 的风险增加有关. 这一元分析证实是GDM发展的潜在风险因素.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 关于血液中 (Mn) 水平与妊娠糖尿病 (GDM) 之间的关联存在不一致的发现.
- 进行了系统性审查和元分析,以澄清孕妇之间的这种关系.
研究的目的:
- 调查血液中含量与妊娠期糖尿病风险之间的关联.
- 综合观察性研究的证据,以更好地了解这种潜在的风险因素.
主要方法:
- 在2023年3月10日之前,对主要电子数据库 (Medline,Embase,Cochrane Library,Web of Science) 进行了系统的搜索.
- 来自五项观察性研究的六个数据集,包括91,249名孕妇,被纳入了元分析.
- 使用随机效应模型汇集数据,并进行子组分析以评估研究特征的影响.
主要成果:
- 高血水平显著与增加GDM风险相关 (OR: 1.31,95% CI: 1.19-1.44,p < .001).
- 在包括的研究中没有观察到显著的异质性 (p = 0.93,I2 = 0%).
- 亚组分析始终支持这种关联,无论研究设计,母亲年龄,Mn测量方法或GDM发病率如何.
结论:
- 血中含量升高可能是孕妇患妊娠糖尿病的危险因素.
- 需要进一步的研究来阐明潜在的生物学机制,并确定血液和GDM风险之间是否存在剂量依赖的关系.
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