生物结合技术用于增强蛋白质和类治疗药物的稳定性和向效率
Tanuja Bisht1, Anupriya Adhikari1, Shivanand Patil1
1Department of Pharmacy, Shree Dev Bhoomi Institute of Education, Science and Technology, Veer Madho Singh Bhandari Uttarakhand Technical University, Dehradun, Uttarakhand, India.
Current protein & peptide science
|November 3, 2023
概括
生物结合策略通过提高稳定性和向性来增强蛋白质和类疗法. 本综述详细介绍了这些先进的药物输送系统的方法,应用和未来方向.
科学领域:
- 生物结合化学的化学
- 制药科学 制药科学
- 药物输送系统是药物输送系统.
背景情况:
- 蛋白质和类疗法在稳定性和向性交付方面面临挑战.
- 生物结合为克服这些局限性提供了解决方案.
- 先进的生物结合技术对于治疗疗效至关重要.
研究的目的:
- 对蛋白质和治疗的生物结合策略进行全面审查.
- 分析增强稳定性,向性和药理动学的方法.
- 讨论分析特征和临床应用.
主要方法:
- 化学和酶生物结合方法的审查.
- 对交叉连接和特定站点的结合方法的分析.
- 检查带附着和受控释放的技术.
主要成果:
- 生物结合显著提高了治疗稳定性和向效率.
- 现有策略可以延长循环时间,并允许控制释放.
- 分析方法对于表征生物合物至关重要.
- 临床前和临床研究证明了生物结合疗法的潜力.
结论:
- 生物结合是开发先进蛋白质和疗法的重要工具.
- 新的结合方法和向策略对未来的药物开发具有前景.
- 优化生物结合可以提高治疗稳定性,疗效和患者的治疗结果.
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