pH值和盐度对半径细胞外基质衍生植入物的微观结构和机械性能的影响
Soraya Salinas-Fernandez1,2,3, Orquidea Garcia4, Daniel J Kelly1,2,3,5
1Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, Dublin, Ireland.
Journal of biomedical materials research. Part A
|November 3, 2023
概括
研究人员使用脱细胞化外细胞矩阵 (dECM) 开发了机械功能阴茎组织等价物. 控制的原纤维化改善了潜在的阴茎修复应用的机械性能.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科手术 整形外科手术
- 组织工程是组织工程.
背景情况:
- 阴茎损伤很常见,通常需要超出组织保存的先进修复策略.
- 目前的工程化阴茎替代品面临机械强度和生物整合方面的挑战.
- 脱细胞化细胞外矩阵 (dECM) 是有前途的,但需要机械增强.
研究的目的:
- 从dECM制造出机械坚固的阴茎组织等价物.
- 为了研究原纤维化对dECM机械性能的影响.
- 评估dECM植入物的生物相容性和手术可行性.
主要方法:
- 通过pH和盐度调整提取dECM和控制的原纤维化.
- 使用dECM造和冷干燥保存制造的阴茎形植入物.
- 评估了机械性能,体外与猪纤维状粒细胞的生物相容性,和线的拉出强度.
主要成果:
- 控制的原纤维化显著提高了dECM结构的机械性能.
- dECM植入物在体外显示出良好的生物相容性.
- 冷干燥使得现货可用,线拉出测试表明了手术固定的可行性.
结论:
- 通过控制原纤维化,可以从dECM制造机械功能阴茎组织等价物.
- 这些基于dECM的植入物显示出作为原生阴茎组织的可行的替代品的潜力.
- 开发的方法为阴茎组织工程和修复提供了一个有前途的方法.
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