队列简介更新:加拿大环境化学物质母婴研究儿童发展研究 (MIREC-CD PLUS)
Mandy Fisher1, Gina Muckle2, Bruce Lanphear3
1Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.
Paediatric and perinatal epidemiology
|November 3, 2023
概括
环境化学品母婴研究 (MIREC) 研究调查了产前化学物质暴露和儿童发育. 后续研究 (MIREC-CD PLUS) 评估了幼儿时期的人类测量和神经发育,并正在进行青少年内分泌和代谢功能研究.
科学领域:
- 环境健康科学 环境健康科学
- 儿科流行病学 儿科流行病学
- 发育毒理学 发展毒理学
背景情况:
- 全加拿大环境化学物质母婴研究 (MIREC) 研究最初侧重于母亲的环境化学物质暴露和不良妊娠结果.
- 该MIREC研究招募了2001名孕妇,以评估化学物质暴露与怀孕健康之间的联系.
研究的目的:
- 该MIREC-儿童发育 (CD PLUS) 研究旨在评估产前化学物质暴露对儿童早期人类学和神经发育的影响.
- 这项研究扩展了MIREC队列,以调查青春期的长期影响,特别关注内分泌和代谢功能 (MIREC-ENDO).
主要方法:
- 在MIREC-CD PLUS研究中,从最初的MIREC队列中邀请了1459个家庭,其中有15个月至5岁的儿童.
- 数据收集包括在线母体自我管理问卷,生物监测 (血液和尿液样本) 和神经发育评估在两次面对面访问期间.
- 神经发育评估包括标准化测试,如执行功能的行为评分清单和韦克斯勒学龄前小学智力初级尺度-III.
主要成果:
- 在2013年4月至2015年3月期间,803名儿童接受了生物监测,进行了人体测量,收集了血液和尿液.
- 近900名儿童获得了神经发育数据,包括认知,行为和沟通评估.
- 对610名单独生子进行了神经心理评估,并继续在青春期早期对内分泌和代谢功能进行随访.
结论:
- 对于MIREC-CD PLUS的数据收集已经完成,正在进行的分析继续探索早期暴露与儿童发育之间的关联.
- 该研究承认其局限性,包括参与者消耗和主要较高的社会经济地位和白人族裔队列,影响了概括性.
- 尽管有局限性,MIREC研究的综合生物监测和临床数据为研究环境暴露对儿童生长和发育的影响提供了宝贵的平台.
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