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在患有脑小血管疾病的患者中,MRI白质超强度和步行功能的不匹配

Lingshan Wu¹, Ziyue Wang¹, Xirui Zhou¹

¹Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Journal of magnetic resonance imaging : JMRI

|November 3, 2023

概括

特定白质道的微观结构损伤可能解释了为什么一些严重白质过强度 (WMH) 的个体会出现走路障碍,而另一些人则没有. 这一发现突出了将WMH严重程度与步行障碍联系起来的潜在机制.

科学领域:

神经成像是一种神经成像.
神经学神经学
老年学是一门学科.

背景情况:

大脑小血管疾病 (CSVD) 与步行障碍有关,MRI上的白质超强度 (WMH) 与步行速度负相关.
然而,并非所有患有WMH的人都会发展出步态问题,这表明除了WMH严重程度之外还有潜在的机制.

研究的目的:

调查严重WMH患者的WMH严重程度和步行障碍之间的差异背后的机制 (Fazekas 3).
为了确定严重的WMH患者与没有步行障碍之间的特定微观结构白质差异.

主要方法:

一项队列研究将54名患有严重WMH和步态障碍 (WMH-GD) 的受试者与114名患有严重WMH但没有步态障碍 (WMH-nGD) 的受试者进行比较.
扩散张力成像 (DTI) 和基于痕迹的空间统计 (TBSS) 用于分析白物质微观结构 (微分异构 - FA).
评估了CSVD和步态参数的常规MRI标志物 (例如,时间起身测试).

主要成果:

与WMH-nGD组相比,WMH-nGD组在特定的白质道中显著减少了FA,包括体和上纵,与WMH-GD组相比.
降低的FA值独立地与时间上升和移动测试的表现较差,步行速度较慢和步伐长度较短有关.
即使对传统的CSVD标记进行调整后,也观察到这些微观结构变化.

结论:

这项研究表明,在患有严重WMH和步态障碍的个体中,特定纤维通道的微观结构性白质损伤.
这些发现为在CSVD患者中观察到的WMH严重程度和步行障碍之间的不匹配提供了潜在的解释.

关键词:

大脑小血管疾病大脑小血管疾病扩散张力成像的成像方法步态障碍步态障碍步态障碍基于路径的空间统计数据.白质的超强度是白质的超强度.

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