来自深海衍生真菌Trichobotrys排泄物的抗炎性Phomalones FS52222
Hui-Bin Huang1,2, Yu-Chan Chen2, Ting-Yue Wen1,2
1School of Pharmacy, Guangdong Pharmaceutical University, 280 Huandong Road, University City, Panyu District Guangzhou, 510006, China.
Chemistry & biodiversity
|November 3, 2023
概括
在深海真菌中发现了四种新的phomalone. 化合物4,6和8显著抑制了氧化 (NO) 生产,表明潜在的治疗应用.
科学领域:
- 海洋天然产品 化学 化学
- 菌类代谢学 菌类代谢学
- 免疫调节化合物的发现
背景情况:
- 深海真菌是新生物活性化合物的尚未开发的来源.
- 研究的化学成分是Trichobotrys effuse FS522,一种从深海环境中分离出来的真菌.
- 之前对相关真菌物种的研究已经确定了具有多种生物活动的化合物.
研究的目的:
- 从深海真菌Trichobotrys出泄物FS522中分离和描述新的化学实体.
- 评估分离化合物的免疫调节潜力,特别是它们对氧化生产的影响.
- 为了确定新型马龙类似物的结构和绝对配置.
主要方法:
- 使用色谱技术分离化合物.
- 使用核磁共振 (NMR) 谱学和高分辨率电喷射电离化质谱学 (HR-ESI-MS) 阐明结构.
- 通过电子循环二元化 (ECD) 计算来确定绝对配置.
- 抑制氧化 (NO) 生产的测定.
主要成果:
- 隔离了四种新的phomalones,被指定为AD (1-4),以及五种已知的类似物 (5-9).
- 新化合物的结构完全通过全面的光谱分析来表征.
- 化合物2的绝对配置是使用ECD计算来确定的.
- 化合物4,6和8显著抑制了氧化的产生,其IC50值分别为4.64μM,13.90μM和34.07μM.
结论:
- 深海真菌Trichobotrys的排泄物FS522产生了新的马龙衍生物.
- 化合物4,6和8表现出强大的氧化抑制活性,表明潜在的抗炎药物.
- 需要进一步研究这些马龙的作用机制和治疗潜力.
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