蓝干预通过调节肠道微生物来缓解有害的微生物代谢物三甲基胺N-氧化物
Adhini Kuppuswamy Satheesh Babu1, Chrissa Petersen1, Lisard Iglesias-Carres2
1Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, Utah, USA.
BioFactors (Oxford, England)
|November 3, 2023
概括
饮食蓝通过改变肠道微生物显著降低了三甲基胺-N-氧化物 (TMAO),这表明它在预防TMAO相关疾病方面发挥了作用. 草没有显示任何影响.
科学领域:
- 微生物学 微生物学
- 营养 营养 营养 营养 营养
- 代谢过程中的代谢.
背景情况:
- 肠道微生物产生代谢物,影响宿主生理.
- 高水平的三甲基胺-N-氧化物 (TMAO) 与诸如心血管疾病,糖尿病和癌症等慢性疾病有关.
- 饮食中的胆和L-卡尼丁被肠道细菌代谢成TMAO.
研究的目的:
- 研究饮食蓝和草对TMA/TMAO生产的影响.
- 探索肠道微生物在调解果消费对TMAO水平影响中的作用.
主要方法:
- 在12周的时间里,小鼠吃了控制,蓝或草饮食,有些小鼠接受了抗生素治疗.
- 评估了代谢参数,胆,TMA和TMAO水平.
- 对果粉进行了微生物分析和醇分析.
主要成果:
- 蓝补充剂 (1.5人份) 在不改变胆或TMA的情况下减少了~48%的循环TMAO.
- 草补充剂没有影响TMAO,胆或TMA水平.
- 抗生素治疗大大减少了TMA和TMAO,证实了肠道微生物的作用.
- 蓝增加了与TMA/TMAO负相关的细菌种群,可能是由于酸.
结论:
- 饮食蓝可以降低循环TMAO水平,可能是通过调节肠道微生物群组成.
- 蓝可能提供一种饮食策略,以预防与TMAO相关的健康并发症.
- 肠道微生物是从食前体产生的TMAO生产的关键调解者.
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