患有胆囊粘囊的狗的并发性肝病症:患病率,预测因素和对长期结果的影响
Sara A Jablonski1, Yue Xiang Polly Chen2, Jarod E Williams2
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Journal of veterinary internal medicine
|November 3, 2023
概括
肝组织学异常在患有胆囊粘囊 (GBM) 的狗中很普遍,纤维化会影响存活率. 增加中性粒细胞与淋巴细胞的比率 (NLR) 可能预测肝脏缩和炎症在GBM狗.
科学领域:
- 兽医病理学 兽医病理学
- 狗医疗 狗医疗 狗医疗
背景情况:
- 胆囊粘膜 (GBM) 是一种常见的犬病状况.
- 有限的数据存在于同时肝脏组织学异常的狗与GBM.
研究的目的:
- 确定患有GBM的狗肝组织学异常的患病率.
- 评估肝脏异常与胆囊切除术后的结果之间的关联.
- 评估具有或没有特定肝病变的狗中中性粒细胞与淋巴细胞比率 (NLR) 的差异.
主要方法:
- 对52只确诊GBM的狗进行了回顾性多中心研究.
- 盲目的调查人员对肝脏活检的组织学评估.
- 基于肝脏发现的生存率和NLR的比较.
主要成果:
- 98%的GBM狗至少有一种肝脏异常.
- 肝纤维化 (73%),胆道增生 (56%) 和门口炎 (48%) 是最常见的.
- 较高的纤维化得分与长期存活率降低相关;高的NLR与肝脏亡和胆管炎/胆管肝炎相关.
结论:
- 肝脏组织学异常在GBM的狗中几乎是普遍存在的.
- 纤维化严重程度是胆囊切除术后生存的潜在预后指标.
- 在GBM病例中,NLR可以作为特定肝病变的预测生物标志物.
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