艾滋病毒感染者滥用酒精的简短干预:一个元分析
Abhishek Ghosh1, Geetesh K Singh2, Nidhi Yadav1
1Drug Deaddiction and Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
The American journal of drug and alcohol abuse
|November 3, 2023
概括
简短的干预措施显著降低了艾滋病毒感染者 (PLHIV) 滥用酒精的人的酒精消费和死亡风险. 这些干预措施可以改善饮酒日,降低死亡率,但不会影响艾滋病毒治疗结果.
科学领域:
- 公共卫生 公共卫生
- 成 药物 药物 药物 药物
- 传染病流行病学 传染病流行病学
背景情况:
- 滥用酒精影响着三分之一的艾滋病毒感染者 (PLHIV),对艾滋病毒疾病的进展和结果产生负面影响.
- 有害或危险的酒精使用是PLHIV的重要并发症,使治疗和管理复杂化.
- 了解PLHIV中滥用酒精的干预措施的有效性对于改善患者健康和寿命至关重要.
研究的目的:
- 评估短期干预措施 (BI) 在改善酒精滥用和与艾滋病毒相关的结果中对滥用酒精的PLHIV的有效性.
- 综合随机临床试验 (RCT) 关于BI对饮酒模式和该人口死亡率的影响的证据.
- 在艾滋病毒和酒精共患病的背景下,确定BI所影响的特定结果.
主要方法:
- 1990年至2022年9月期间发表的随机临床试验 (RCT) 的元分析.
- 纳入标准侧重于有害/危险饮酒成年人和PLHIV.
- 在主要数据库 (MEDLINE,EMBASE,Cochrane,ClinicalTrials.gov,WHO ICTRP) 进行了搜索,并使用Cochrane的工具进行了偏见风险评估.
主要成果:
- 在干预后3-6个月,BI显著减少了每天饮酒量 (Hedge's g = -0.45) 和重度饮酒日数 (Hedge's g = -0.81).
- 在6-12个月内,BI与42%的死亡率 (OR = 0.58) 降低有关.
- BI并没有显著改变酒精风险得分,过渡到有害酒精使用,抗逆转录病毒疗法 (ART) 坚持或病毒抑制.
结论:
- 简短的干预措施可以有效地减少艾滋病毒感染者饮酒和死亡率.
- 建议将查和简短干预服务纳入艾滋病毒诊所和初级保健机构.
- 可能需要进一步的研究来探索BI对PLHIV的ART坚持和病毒抑制的影响.
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