在男性中,前静脉内皮细胞ETB受体蛋白表达与衰老保持一致
Saumya Tummala1,2, Andrew V Kuczmarski1, Angelica R Del Vecchio1
1Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, United States.
American journal of physiology. Heart and circulatory physiology
|November 3, 2023
概括
内皮细胞内素-B受体 (ETBR) 蛋白质表达在老年男性中保持稳定,与女性不同. 这一发现突显了老化内皮质素系统和心血管健康的显著性别差异.
科学领域:
- 心血管生理学心血管生理学
- 衰老研究研究 衰老研究
- 内皮细胞生物学 内皮细胞生物学
背景情况:
- 内皮功能障碍是心血管疾病 (CVD) 的早期标志物.
- 之前的研究表明,随着女性的老龄化,内皮内素-B受体 (ETBR) 蛋白质表达减少,与内皮功能障碍有关.
- 老龄化对男性ETBR蛋白表达的影响仍未得到研究.
研究的目的:
- 调查ETBR蛋白表达是否在老年男性 (OM) 与年轻男性 (YM) 相比减弱.
- 为了探索潜在的性别差异与年龄相关的变化,内甲蛋白系统.
主要方法:
- 从14个OM和17个YM的前静脉中分离出初级内皮细胞.
- 免疫细胞化学被用来量化ETBR蛋白表达.
- 通过手臂动脉流媒扩张 (FMD) 评估内皮功能;血压和水平也被测量.
主要成果:
- 在OM中,透缩血压较高,总丸激素较低.
- 正如预期的那样,与YM相比,OM的口病在OM中明显较低.
- 然而,ETBR蛋白表达水平在OM和YM之间是相似的.
结论:
- 在男性中,内皮细胞ETBR蛋白表达与衰老保持一致.
- 这些发现与先前在女性中的观察结果形成鲜明对比,支持衰老内甲蛋白系统中独特的基于性别的机制.
- 这项研究强调了在心血管衰老研究中将性别视为生物变量的重要性.
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