在分娩后的早期,不良妊娠结果和血管功能
Abbi Lane1, Marcey Jiles2, Kaitlyn Ramey2
1Department of Applied Exercise Science, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.
American journal of physiology. Heart and circulatory physiology
|November 3, 2023
概括
不良妊娠结果 (APOs) 与更高的心血管疾病风险有关. 在分娩后,患有APO的个体表现出血压升高和阿尔多水平降低,表明潜在的血体积调节问题.
科学领域:
- 心血管健康 心血管健康
- 生殖内分泌学 生殖内分泌学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 负面的妊娠结果 (APO) 会增加长期心血管疾病 (CVD) 的风险.
- 传统的CVD风险因素可能无法充分识别APO后高风险个体.
- 在APO后早期检测生理变化对于预防心血管疾病至关重要.
研究的目的:
- 为了调查血管功能是否受损,以及调节血体积的激素是否在分娩后减少,在有APO病史的个体中.
- 为了比较具有和没有APO病史的个体之间的生理测量.
主要方法:
- 在分娩后6个月至3年,对成年参与者的横截面研究.
- 不包括目前的吸烟者,某些药物使用者,以及以前患有糖尿病的人.
- 使用t测试,威尔科克森测试和线性回归,在使用t测试,威尔科克森测试和线性回归的组之间比较血压,动脉硬,内皮功能和激素 (阿尔多,素) 的血水平.
主要成果:
- 与没有APO的参与者相比,具有APO史的参与者BMI较高,手臂和大动脉血压升高.
- 两组之间在动脉硬度或内皮功能方面没有发现显著差异.
- 参与者有阿波史的阿尔多水平显著降低,在调整后,这种关联仍然存在.
结论:
- 怀孕前史有不良结果的个体在产后早期表现出心血管和荷尔蒙状况的改变.
- 在APO后的个体中,较低的阿尔多斯特水平表明潜在的血体积失调有助于增加心血管疾病风险.
- 需要进一步的研究来追踪血管功能和脏激素在整个产前期,以更好地了解心血管疾病风险轨迹.
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