人类的衰老和同情转化为血压:方法和生理方面的考虑
Jeremy A Bigalke1,2, Benjamin E Young3,4, Emily L Cleveland5
1Robbins College of Health and Human Sciences, Baylor University, Waco, Texas, United States.
American journal of physiology. Heart and circulatory physiology
|November 3, 2023
概括
老龄化增加了交感神经活动,突发高于平均血压,但这并不能完全解释老年人血压转导减少的原因. 这表明与年龄相关的同情控制下降是由于压力对神经爆发的反应减少.
科学领域:
- 生理学 生理学 生理学
- 心血管科学 心血管科学
- 神经科学是一个神经科学.
背景情况:
- 交感转导的量化受到肌肉交感神经活动 (MSNA) 和平均动脉压 (MAP) 的影响.
- 与年龄相关的交感转导减少尚未完全理解.
- 之前的报道表明MSNA和爆发发生相对于MAP影响转导量化.
研究的目的:
- 调查休息MSNA和相对于MAP的爆发发生如何影响与年龄相关的交感转导的减少.
- 为了确定老年人中超过平均MAP的交感突发增加是否解释了形转导.
- 为了检查交感爆发,MAP和血压调节中与年龄相关的变化之间的关系.
主要方法:
- 在27名年轻和26名年长的健康成年人中记录了节拍血压和MSNA.
- 信号平均MSNA爆发和计算的转导在低,中,和高的MAP地板内.
- 分析的爆发发生比例高于平均MAP和相关的压力/压力反应.
主要成果:
- 老年人与年轻人相比,休息时MSNA较高,但MAP相似.
- 较年长的成年人表现出整体MAP转导的减弱 (Δ0.9 ± 0.7 mmHg) 与较年轻的成年人 (Δ1.5 ± 0.6 mmHg) 相比.
- 在老年人中,同情性爆发的比例高于平均MAP,与抑郁反应相关;然而,压力反应期间的转导减少在各组之间是相似的.
结论:
- 衰老与发生在平均血压以上的更多同情性爆发有关.
- 爆发发生率高于平均MAP的增加不仅仅解释了老年人形交感转导.
- 与年龄相关的交感转导的下降是由对交感爆发的压力反应减少所支持的,独立于绝对血压水平.
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