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Updated: Jul 11, 2025

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通过数据融合和多数投票制定可靠的IDO1/TDO双重抑制剂分类

Zahra Ghaemi1, M Asadollahi-Baboli1

  • 1Department of Chemistry, Faculty of Science, Babol Noshirvani University of Technology, Babol, Mazandaran, Iran.

Journal of biomolecular structure & dynamics
|November 3, 2023
PubMed
概括

这项研究开发了一种可靠的方法,使用数据融合和多数投票来识别癌症和神经退行性疾病的双重IDO1/TDO抑制剂. 该方法显著提高了活性和非活性化合物的分类准确性.

关键词:
分类 分类 分类 分类.数据融合数据融合胺 2,3-二氧化基酶 1 1 胺 2,3-二氧化基酶 1 1大多数投票方式.托 2,3-二氧化基酶的使用

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Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
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