葡萄糖酸盐在癌症预防和治疗中的作用:实验和临床证据
Neda Orouji1, Siamak Kazemi Asl2, Zahra Taghipour1
1Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, 1417653761, Iran.
Medical oncology (Northwood, London, England)
|November 3, 2023
概括
葡萄糖酸盐及其异基酸盐代谢产物通过向各种细胞通路,显示出有希望的抗癌作用. 然而,需要进一步的研究来确定最佳的,癌症治疗的安全剂量.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 葡萄糖类酸盐是Brassicaceae植物中发现的β-d-thioglucosides.
- 胺基酶将葡萄糖酸盐转化为异硫酸酸盐,它们以其保护作用而闻名.
- 某些特定的异基酸盐,如乙烯异基酸盐,硫福拉和乙烯异基酸盐,具有抗癌性质.
研究的目的:
- 研究葡萄糖酸盐及其代谢物的癌症预防和治疗机制.
- 探索参与其抗癌活动的分子通路.
- 突出需要进一步研究治疗应用的最佳剂量.
主要方法:
- 审查关于葡萄糖酸盐和异硫酸酸盐的现有文献.
- 分析分子机制,包括Nrf2诱导,亡和免疫调节.
- 对血管生成,自然杀伤细胞和关键癌症相关蛋白质 (p53,p21,caspases) 的影响的检查.
主要成果:
- 葡萄糖酸盐代谢物通过Nrf2激活癌症预防,抑制炎症性细胞因子 (TNFα,IL-1β),并诱导亡.
- 它们调节I/II相酶,酶通路和STAT信号.
- 治疗效果包括抑制血管生成,增强自然杀手细胞活性,并上调瘤抑制剂 (p53,p21).
结论:
- 葡萄糖酸盐和异酸盐通过各种机制具有预防和治疗癌症的巨大潜力.
- 关键细胞通路和免疫反应的调节有助于它们的抗癌疗效.
- 由于与某些异硫酸酸盐相关的潜在风险,仔细的剂量确定至关重要,需要进一步调查.
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