选择性雌激素受体调节剂和深静脉血栓症在老年妇女的新兴手术后
Keiko Kishida1, Masanobu Furukawa1, Masayuki Nakashima2
1Phamaceutics, Yoka Municipal Hospital, Yabu, Hyogo, 667-8555, Japan.
JA clinical reports
|November 3, 2023
概括
选择性雌激素受体调节剂 (SERM) 可能会增加深静脉血栓形成 (DVT) 的风险,在接受紧急手术的患者. 建议这些人进行术后超声波查,以监测DVT的发展.
科学领域:
- 老年医学 老年医学
- 药理学 药理学 是一个学科.
- 血管外科 血管外科
背景情况:
- 选择性雌激素受体调节剂 (SERM) 用于骨质疏松症治疗.
- 在SERM中存在深静脉血栓形成的潜在风险 (DVT).
- 在选择性手术之前,通常需要停止SERM,但对于紧急手术来说不可行.
研究的目的:
- 为了研究在SERM治疗期间接受紧急骨科手术的老年患者的DVT发病率.
- 评估在接受SERM治疗骨质疏松症的患者手术后的DVT风险.
主要方法:
- 对接受紧急骨科手术的老年患者进行回顾性病例审查.
- 在手术前服用SERM的患者中对DVT发展的分析.
- 在研究患者队列中计算DVT发生率.
主要成果:
- 接受SERM治疗的八分之二的老年患者 (25%的发病率) 在手术后出现新的或恶化的DVT.
- 在接受下肢突发性骨科手术的患者中发生了DVT.
- 在其他六名接受类似手术的患者中没有发生DVT,他们也在SERM上.
结论:
- 服用SERM的患者的紧急手术可能与DVT的风险增加有关.
- 对于接受手术的SERM患者,建议进行术后超声波检查.
- 需要进一步的研究来澄清SERM在手术患者中的风险益处概况.
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