接种SARS-CoV-2疫苗和多发性硬化症:一项大型多中心研究,研究第三次强剂后复发风险
Massimiliano Di Filippo1, Diana Ferraro2, Paolo Ragonese3
1Clinica Neurologica, Dipartimento di Medicina e Chirurgia, Università di Perugia, Perugia, Umbria, Italy. massimiliano.difilippo@unipg.it.
Journal of neurology
|November 3, 2023
概括
第三次COVID-19疫苗增剂剂量对于患有多发性硬化症 (pwMS) 的人来说是安全的. 一项研究发现,增剂后疾病复发率没有增加,这表明该群体的安全性很好.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 患有多发性硬化症 (pwMS) 的人接受了COVID-19疫苗,推增强剂量以维持免疫力.
- 关于pwMS中第三次mRNACOVID-19疫苗增剂剂量安全性的数据有限,特别是关于疾病恶化.
研究的目的:
- 评估第三次mRNA COVID-19疫苗增剂剂量是否会增加 pwMS.中疾病再激活的短期风险.
- 在多发性硬化症队列中评估COVID-19疫苗增强剂的安全概况.
主要方法:
- 一项回顾性研究包括1265名pwMS,他们接受了第三次mRNA COVID-19疫苗增剂.
- 收集和分析了临床数据,包括在增剂前后60天内复发的临床数据.
主要成果:
- 与前两个月相比,pwMS的复发率在第三次mRNACOVID-19疫苗增剂后的两个月内没有增加.
- 经历复发的pwMS的百分比是后补充剂的2.1%,而前补充剂的1.9%.
结论:
- 这些发现表明,第三次mRNA COVID-19疫苗增剂剂对于患有多发性硬化症的人来说是安全的.
- 在补充疫苗接种后,没有观察到增加疾病重新激活的证据.
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