骨质,矿物质密度,以及心力衰竭中的骨折
Andre Luiz Canteri1,2, Luana Bassan Gusmon1, Cesar Luiz Boguszewski2,3
1Division of Cardiology, Department of Internal Medicine, Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná State, Brazil.
PloS one
|November 3, 2023
概括
心力衰竭患者的骨质较差,骨骨分数 (TBS) 提供比单独的骨矿物密度 (BMD) 更好的骨折预测,特别是在正常的BMD病例中. 经过TBS调整,可以提高骨折风险评估.
科学领域:
- 心脏病学 心脏病学
- 骨质疏松症研究 骨质疏松症研究
- 骨质的质量评估 骨质的质量评估
背景情况:
- 脊椎骨评分 (TBS) 评估骨质量,并独立于骨矿物质密度 (BMD) 预测骨折.
- 关于骨健康和心脏病之间的联系的数据有限,特别是关于TBS.
- 调查心力衰竭患者的TBS对于了解这一群体的骨质量至关重要.
研究的目的:
- 评估心骨分数 (TBS),骨矿物密度 (BMD) 和心力衰竭患者中骨折的患病率与减少喷射率 (HFrEF).
- 使用FRAX评估骨折概率,包括脊椎骨折评估 (VFA) 和TBS调整.
- 在HFrEF患者中识别与减少TBS相关的因素.
主要方法:
- 横截面研究比较HFrEF患者与匹配的对照.
- 使用脊椎骨折评估 (VFA) 评估TBS,BMD和骨折的评估.
- 使用FRAX进行骨折风险评估,对TBS进行调整.
主要成果:
- 总体而言,HFrEF患者和对照人群之间TBS没有显著差异,但在正常骨质量患者中较低.
- 减少TBS与年龄,较低的白蛋白,他类药物的使用和能量摄入有关.
- 脊椎骨折评估 (VFA) 在42.4%的HFrEF患者中发现了骨折.
- 经过TBS调整,骨折风险预测增加了16% - 23% .
结论:
- 患有HFrEF的患者表现出较差的骨质,TBS是骨折风险评估的宝贵工具,特别是当骨质量正常时.
- 预后因素,严重性标志物和HFrEF的治疗方法与TBS的减少有关.
- 结合VFA和TBS调整可以改善HFrEF患者骨折风险分层.
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