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Updated: Jul 11, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

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在动态螺旋式金属密码中,用性金属离子结合来加速和减速性反转速度

Sk Asif Ikbal1, Pei Zhao2, Masahiro Ehara2

  • 1Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

Science advances
|November 3, 2023
PubMed
概括

一个trinickel(II) 密码的奇拉性反转动力学是由客人识别控制的. 金属离子结合改变了P/M平衡和反转率,证明了可调节的分子动力学.

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The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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