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Updated: Jul 11, 2025

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在 nociceptors 中的4E-BP1-依赖翻译通过TRIM32/I型干扰素信号传递控制机械过敏性

Calvin Wong1, Diana Tavares-Ferreira2, Carolina Thörn Perez1,3

  • 1Department of Anaesthesia, McGill University, Montreal, Canada.

Science advances
|November 3, 2023
PubMed
概括

拉巴胺素复合体1 (mTORC1) 激活的机械标会导致慢性疼痛过敏. 这项研究表明,mTORC1通过4E-BP1在痛感受体中对TRIM32进行上调,促进疼痛信号传递并提供治疗点.

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