固体器官移植接受者的COVID-19后急性后果
Rachel Sigler1, Karina Covarrubias2, Benjamin Chen3
1Division of Infectious Diseases, The University of Kansas Health System, Kansas City, Kansas, USA.
概括
COVID-19 (PASC) 后急性后果影响了大约三分之一的实体器官移植接受者. 移植前接种疫苗可能会降低PASC的风险,需要进一步调查.
科学领域:
- 移植医学 移植医学
- 传染病 传染病 传染病
- 免疫学 免疫学 免疫学
背景情况:
- 冠状病毒疾病2019 (COVID-19) (PASC) 后急性后果在固体器官移植接受者 (SOTR) 中没有很好的特征.
- 在SOTR中理解PASC是非常重要的,因为它们的免疫功能受损.
研究的目的:
- 评估SOTR中PASC的流行情况.
- 描述PASC的特征,并确定该群体中相关的风险因素.
主要方法:
- 在2020年6月至2022年4月期间,对急性COVID-19的SOTR进行了回顾性研究.
- 抽象的数据包括人口统计,病史,急性COVID-19特征和疫苗接种状态.
- PASC被定义为在急性COVID-19诊断后持续≥6周的症状.
主要成果:
- 在208个国家统治区中,PASC在72个国家 (35%) 发展.
- 常见的PASC症状包括呼吸问题 (67%),头痛 (40%) 和难以集中注意力 (10%).
- 严重的急性COVID-19和呼吸系统症状增加了PASC的几率;移植前接种疫苗显示有保护作用.
结论:
- 帕斯克影响约三分之一的SOTRs,症状类似于免疫能力强的个体.
- 移植前的COVID-19疫苗接种可能有助于预防PASC的发展.
- 建议进行进一步的前性多中心研究来验证这些发现.
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